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          1. DISEASE MOUSE MODELS

            Model animals, as an important tool for human disease research, aid in the investigation of disease mechanisms and the development of therapies. Mouse models, being the most extensively used model animals, are employed in a variety of areas, such as fundamental scientific research, drug discovery, preclinical evaluation, and clinical technology development. Mice have a close relationship with humans, advanced genetic manipulation, fast reproduction, and a clear genetic background. Gene editing technology can provide suitable disease models for study based on disease-related genes. GemPharmatech has produced numerous disease models using gene editing technologies, such as spontaneous tumor models, obesity models, diabetes models, Alzheimer's disease models, Parkinson's disease models, and so on. Through phenotypic analysis, GemPharmatech has also confirmed the incidence and development of numerous model-related phenotypes, providing solid support for the research of various diseases.

            Introducing GemPharmatech's Latest Strains: Unveiling the Future of Innovation


            Strain ID

            Strain Name

            Application

            T055223


            B6-Tg(hSOD1 G93A,hSOD1) 圖片1.png

            Genetic humanization, ALS disease

            T058996

            FAD4T-hTREM2 圖片1.png

            Genetic humanization, Alzheimer's disease

            T054322

            B6-hSNCA E46K A53T

            Genetic humanization, Parkinson's disease

            T056757

            B6-hCD36

            Genetic humanization, neuroinflammation

            T056002

            B6-Dmd Del45

            Duchenne muscular dystrophy, 45 exon deletion

            T055631

            B6-hDLL4

            Genetic humanization, oncology

            T056429

            B6-hCD34

            Genetic humanization, oncology

            T058753

            B6-hCEACAM5-Tg

            Genetic humanization, oncology

            T053316

            B6-hIL18R1/hIL18RAP

            Genetic humanization, oncology

            T037007

            B6-hCD47/hSIRPA 圖片1.png

            Genetic humanization, oncology

            T056010

            BALB/c-hCD44

            Genetic humanization, oncology

            T054198

            BALB/c-hGPC3

            Genetic humanization, oncology

            T054490

            BALB/c-hSEMA4D

            Genetic humanization, oncology

            T054543

            BALB/c-hHSA

            Genetic humanization, oncology

            T056432

            BALB/c-hTROP2 圖片1.png

            Genetic humanization, oncology

            T056011

            BALB/c-hCD44v6

            Genetic humanization, oncology

            T055714

            BALB/c-hCS1

            Genetic humanization, oncology

            T056083

            BALB/c-hLRRC15

            Genetic humanization, oncology

            T056430

            BALB/c-hNECTIN-4

            Genetic humanization, oncology

            T058266

            BALB/c-hTIGIT/hPVRIG

            Genetic humanization, oncology

            T054842

            BALB/c-hPD1/hPDL1/hTIGIT/hCD9 圖片1.png

            Genetic humanization, oncology

            T058749

            BALB/c-hPD1/hPDL1/hCD73/hCD39 圖片1.png

            Genetic humanization, oncology

            T009819


            BALB/c-hHER2 圖片1.png


            Genetic humanization, oncology

            T009813

            NCG-hHER2

            Genetic humanization, oncology

            T054081

            NOD-Scid-hNKp30

            Genetic humanization, oncology

            T056195

            B6-hIGHA1

            Genetic humanization, autoimmune disease


            T054583

            BALB/c-hIL1RL1

            Genetic humanization, autoimmune disease

            T054645

            BALB/c-hKLRB1

            Genetic humanization, autoimmune disease

            T003277

            BALB/c-hIL17A 圖片1.png

            Genetic humanization, autoimmune disease

            T053555

            BALB/c-hIL1β

            Genetic humanization, autoimmune disease

            T054186

            BALB/c-hTLR8

            Genetic humanization, autoimmune disease

            T055268

            BALB/c-hFcgRs/hCD47/hSIRPA 圖片1.png

            Genetic humanization, Fc end modification for antibody drugs, ADCC effect

            T058940

            BALB/c-hCD3EDG/hCD22

            Genetic humanization, CD3 bispecific antibody related

            T057420

            BALB/c-hCD73/hCD3EDG 

            Genetic humanization, CD3 bispecific antibody related

            T058817

            BALB/c-hGPRC5D/hCD3EDG 圖片1.png

            Genetic humanization, CD3 bispecific antibody related

            T059045

            BALB/c-hCD3EDG/hBCMA 圖片1.png

            Genetic humanization, CD3 bispecific antibody related

            T058351

            B6-Rosa26-hAGT 圖片1.png

            Genetic humanization, hypertension

            T058352

            B6-H11-hREN

            Genetic humanization, hypertension

            T054639

            B6-hCD200R1

            Genetic humanization, atherosclerosis research

            T058217

            B6-hAPOB-Tg

            Genetic humanization, hypercholesteremia and atherogenesis

            T058211

            B6-hAPOE-DGAT2-LE1 圖片1.png

            Genetic humanization, NASH

            T051403

            B6-Myh6-R404Q 圖片1.png

            Hypertrophic cardiomyopathy

            T027708

            B6-Mybpc3-KO

            hypertrophic cardiomyopathy or dilated cardiomyopathy

            T007085

            B6-Kras-G12D/wt; Lyz2-iCre

            Spontaneous lung cancer

            T053603

            kras-G12C 圖片1.png

            Kras-related spontaneous tumors

            T057165

            KPS 圖片1.png

            Spontaneous lung cancer

            T057162

            KS

            Spontaneous lung cancer


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